Different ways to make stem cell transplantation safer, easier, and more effective are also being studied see Treatment Options.
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Palliative care. If you would like additional information about the latest areas of research regarding AML explore these related items that take you outside of this guide:. To find clinical trials specific to your diagnosis, talk with your doctor or search online clinical trial databases now.
Please note that this link takes you to a separate ASCO website. The next section in this guide is Coping with Treatment. It offers some guidance in how to cope with the physical, emotional, and social changes that AML and its treatment can bring.
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You may use the menu to choose a different section to read in this guide. Looking for More About the Latest Research? If you would like additional information about the latest areas of research regarding AML explore these related items that take you outside of this guide: To find clinical trials specific to your diagnosis, talk with your doctor or search online clinical trial databases now. Types of Cancer. Medical Illustrations.
Symptoms and Signs. Treatment Options. About Clinical Trials. Latest Research. Coping with Treatment. Follow-Up Care. Questions to Ask the Health Care Team. Additional Resources. Laboratory tests reveal increased numbers of cells belonging to the myeloid cell line monocytes, neutrophils, basophils, eosinophils at various stages of development circulating in the blood stream.
Although the cause of leukemia in most patients is unknown, several factors are associated with increased risk of developing the disease. Factors that influence risk of developing leukemia include:. The relative effects of these and other risk factors in any given case of cancer is variable. Some of these and other risk factors are discussed below. Age The risk of developing most types of leukemia increases steadily with age.
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More information about the relationship between cancer and age can be found in the Mutation section. Chemotherapy There is a subset of acute myeloid leukemia AML , known as "secondary AML" or "therapy-related myeloid leukemia," which can develop following treatment with chemotherapy. Although a causal relationship is implied by the name, the exact mechanism remains unknown.
Leukemia also occurs more frequently in males than females. Inherited Syndromes Children with Down syndrome DS have a roughly fold increased risk of developing childhood leukemia compared to children without DS. One to two percent, however, develop a malignant acute leukemia requiring chemotherapy by the age of 4. Although the risk associated with exposure to lower level radiation is not clear, studies have shown an increase in leukemia following the use of radiotherapy for ankylosing spondylitis a form of arthritis and exposure to diagnostic X-rays of the fetus during pregnancy.
Although the exact mechanism by which HTLV-I infection induces cancer is not known, laboratory studies have identified several mechanisms which may be involved. Leukemia results in the accumulation of cancer cells in the bone marrow and blood. The presence of large numbers of abnormal cells in the bone marrow can inhibit the marrow from producing normal healthy blood cells.
Symptoms caused by bone marrow failure include paleness, tiredness, shortness of breath, excessive bleeding, and increased susceptibility to infections. Cancer cells can also infiltrate organs such as the lymph nodes, spleen, and liver leading to swelling.
Biology and relevance of human acute myeloid leukemia stem cells.
The diagnosis of leukemia frequenly occurs following a routine blood test that results in an abnormal blood cell count. Samples are also sent to the pathology lab to identify proteins located on the surface and chromosomal and molecular changes within abnormal cells. Learn more about cancer detection.
Genetic changes that occur in cancer include mutation of key regulatory genes, changes in protein products, and changes in the amount of product produced by genes gene expression. As changes accumulate, cells become more abnormal and cancer progresses. Details of genetic change associated with cancer can be found in the Mutation section. Advances in leukemia research within recent decades have increased our knowledge about the changes that occur in the disease.
A large variety of alterations, including point mutations, amplifications, insertions, deletions, and trisomies are important in development of leukemia. Over chromosomal translocations have been identified so far! A translocation is a rearrangement of parts of a chromosome. Understanding the changes that occur and their effects on cell function allows doctors to classify leukemia into subsets with distinct prognoses and treatment strategies. The example of a common translocation, known as the Philadelphia Chromosome, is discussed below.
Learn more about translocations. Translocations involve chromosome breakage and exchange of chromosome fragments. Part of the proto-oncogene abl is removed from chromosome 9 and joined to the bcr gene on chromosome Similarly, part of chromosome 22 is removed and relocated to chromosome 9. The normal ABL protein functions as a tyrosine kinase. Tyrosine kinases are enzymes that transfer phosphate groups from ATP to other molecules.
Activation of key regulatory enzymes in this manner leads to a cascade of events that ultimately results in cell division.
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The newly created bcr-abl fusion gene located on the Philadelphia chromosome codes for a protein that has increased tyrosine kinase activity, and therefore leads to increased stimulation of cell division, compared to the normal ABL protein. The presence of the drug blocks the binding of ATP, preventing the protein from functioning as a tyrosine kinase. As our focus is on the biology of the cancers and their treatments, we do not give detailed treatment guidelines.
Instead, we link to organizations in the U. The National Cancer Institute lists the following treatments for leukemia:. For more information about how other cancer treatments work, refer to the Cancer Treatments section. Leukemia Risk Factors Mayo Clinic. Risk Factors: Leukemia. Adult Acute Lymphoblastic Leukemia Treatment.
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Adult Acute Myeloid Leukemia Treatment. Chronic Lymphocytic Leukemia Treatment.
Chronic Myelogenous Leukemia Treatment. Hairy Cell Leukemia Treatment. Childhood Acute Lymphoblastic Leukemia Treatment. Childhood Acute Myeloid Leukemia Treatment. Leukemia, Lymphoma Society Report. Leukemia Side Effects. International CML Support. Leukemia and Lymphoma Foundation Canada. Canadian Cancer Society: Leukemia.